In vitro evidence of cellular adaptation to ozone toxicity in the rat trachea
Identifieur interne : 001518 ( Main/Exploration ); précédent : 001517; suivant : 001519In vitro evidence of cellular adaptation to ozone toxicity in the rat trachea
Auteurs : Kristen J. Nikula [États-Unis] ; Dennis W. Wilson [États-Unis] ; Donald L. Dungworth [États-Unis] ; Charles G. Plopper [États-Unis]Source :
- Toxicology and Applied Pharmacology [ 0041-008X ] ; 1988.
English descriptors
- Teeft :
- Academic press, Adaptive decrease, Amer, Biochemical changes, Biochemical effects, Cell damage, Cell density, Cell populations, Cell type, Cellular adaptation, Cilium, Control explant, Culture medium, Degenerate, Degenerative changes, Dungworth, Enzyme activities, Epithelial, Epithelial cells, Epithelial turnover, Epithelium, Experimental animals, Explant, Explant exposure, Explant exposure study, Explant exposure system, Explant exposures, Exposure group, Inhalation exposures, Luminal surface, Migratory cells, Mustafa, Necrotic, Necrotic cells, Neural influences, Nikula, Nitrogen dioxide, Numerical density, Occasional cells, Ozone, Ozone exposure, Preexposed, Preexposure, Preexposure group, Previous exposure, Quantitative electron, Rats preexposed, Secretory, Secretory material, Secretory product influences, Serous cells, Short cilia, Sloughed, Sloughed cells, Standard error, Striking change, Total number, Trachea, Tracheal, Tracheal epithelium, Tracheal explants, Unidentified.
Abstract
Abstract: Adaptation to prolonged ozone (O3) exposure occurs in the tracheal epithelium of rats and is marked by the presence of ciliated cells with uniform short cilia but is not accompanied by shifts in cell populations, altered characteristics of epithelial secretory cell products, increased cell turnover, or elevated tracheal superoxide dismutase activity. The purpose of this study was to test the hypothesis that adaptation is a result of alterations intrinsic to epithelial cells or to the cells and their matrix, and not due to systemic or neural influences. Rats were preexposed to either filtered air (FA) or 0.96 ppm O3 for 8 hr/night for 60 days, and then their tracheae were removed and exposed to 3 ppm O3 in an explant culture system where behavioral, nasal, exudative, and secretory product influences can be eliminated. After exposure to 3 ppm O3 in vitro, quantitative electron microscopic evaluation demonstrated that the epithelia from the FA preexposure group had significantly more necrotic cells and sloughed cells and fewer ciliated cells than the epithelia from the O3 preexposure group. Thus previous exposure to ozone in vivo induces a change in tracheal epithelium which confers resistance to ozone-induced injury in the explant exposure system.
Url:
DOI: 10.1016/0041-008X(88)90042-7
Affiliations:
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The purpose of this study was to test the hypothesis that adaptation is a result of alterations intrinsic to epithelial cells or to the cells and their matrix, and not due to systemic or neural influences. Rats were preexposed to either filtered air (FA) or 0.96 ppm O3 for 8 hr/night for 60 days, and then their tracheae were removed and exposed to 3 ppm O3 in an explant culture system where behavioral, nasal, exudative, and secretory product influences can be eliminated. After exposure to 3 ppm O3 in vitro, quantitative electron microscopic evaluation demonstrated that the epithelia from the FA preexposure group had significantly more necrotic cells and sloughed cells and fewer ciliated cells than the epithelia from the O3 preexposure group. 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